known to be very persistent in the environment,.As a result, today, DDT is classified as a probable human carcinogen by U.S. In addition, some animals exposed to DDT in studies developed liver tumors. Since then, studies have continued, and a relationship between DDT exposure and reproductive effects in humans is suspected, based on studies in animals. In 1972, EPA issued a cancellation order for DDT based on its adverse environmental effects, such as those to wildlife, as well as its potential human health risks. The publication in 1962 of Rachel Carson's Silent Spring stimulated widespread public concern over the dangers of improper pesticide use and the need for better pesticide controls. Environmental Protection Agency in 1970, began regulatory actions in the late 1950s and 1960s to prohibit many of DDT's uses because of mounting evidence of the pesticide's declining benefits and environmental and toxicological effects. Department of Agriculture, the federal agency with responsibility for regulating pesticides before the formation of the U.S. Regulation Due to Health and Environmental Effects DDT's quick success as a pesticide and broad use in the United States and other countries led to the development of resistance by many insect pest species.

It also was effective for insect control in crop and livestock production, institutions, homes, and gardens. It was initially used with great effect to combat malaria, typhus, and the other insect-borne human diseases among both military and civilian populations. DDT (dichloro-diphenyl-trichloroethane) was developed as the first of the modern synthetic insecticides in the 1940s.

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